A small biotech with a promising drug and no money for the last trials writes to a large drug company and asks for a partner. Thousands of such pitches reach some large companies, by portal, email, banker and conference meeting.1 Someone has to read each one, decide whether it deserves an expert's time, and answer it: that first sorting is partnering opportunity triage, the front door of search and evaluation, the team that finds and judges drugs from outside.
This guide is for anyone who reads, routes, answers or pays for that work: search and evaluation (S&E) and business development (BD) teams, therapeutic-area reviewers (scientists who judge pitches in one field of disease), BD counsel, BD operations, and biotech founders who want to know what happens to a deck after they press send. No background needed.
Imagine you are the Director of Search & Evaluation at Northwind Bio, a large drug company. It is Wednesday, October 7, 2026. Sixteen pitches have arrived since September 22, and your company promises every sender a first reply within 10 business days. Monday's portal brought a 14-slide overview of QH-1187, an antibody for ulcerative colitis, from a company in Suzhou called Qingmere Biologics. Neither name is in your memory. Comparable deals put it at about $1.3 billion, $75 million of it up front.
A new name from a new company would go to the back of the queue. Then someone reads slide 2, and checks the file from May.
The new deck
Asset
QH-1187
Company
Qingmere Biologics, "formerly Rivergate Bio"
Data
Phase 1b, week 12: 33% vs 7% on placebo
Your file, May 12
Asset
RGB-07
Company
Rivergate Bio, same contact, same manufacturer
Reviewer said
"Come back with Phase 1b data"
A stranger's first pitchThe same molecule, returning as askedeight business days left on your promise.
Your immunology reviewer asked for exactly this, the results of a small early study in patients, five months ago. Without the match, the company gets a form letter from the people who invited it back.
What careful triage catches: the same molecule under a new code and a new company name, with time still left to answer.
How a biopharma company sorts the pitches it never asked for
Where inbound partnering opportunities come from, what a first reader must decide, which file must stay closed, how fit is scored, and what the 2026 rules on China-origin assets mean for the desk. Nothing here sells anything. If you are new to drug licensing, start here.
01 · In plain words
Partnering opportunity triage explained: reading every pitch once, and answering every sender
Developing a medicine costs more than most young companies can raise. So a biotech with an early success often looks for a larger company to license its drug: the large company pays money up front, more as the drug passes each milestone, and a royalty on sales, and in return runs the expensive trials and sells the product. Large drug companies want these deals as much as biotechs do. A consulting review in 2021 counted close to 60% of new therapeutic drugs over the prior five years as sourced from outside the company.2
That makes large companies the target of a steady stream of pitches. A biotech fills in the form on a company's partnering portal. A chief executive emails a slide deck to the BD inbox. A banker sends a two-page teaser with a date for first bids. A BD manager comes home from a partnering conference with notes from thirty short meetings. A large drugmaker's business development leader told a 2024 panel that "thousands of opportunities" find their way through the doors at some large companies.1
The team that handles this flow is usually called search and evaluation. Its first job is triage, and the word is meant as hospitals mean it: look at everyone quickly, decide who needs a specialist now, and tell the rest what happens next. A reader logs the pitch, checks that it is safe to open, reads it, asks whether the company has seen this molecule before, scores it against what the therapeutic area, such as immunology, has said it wants, and picks the reviewer. Most pitches stop there, with a courteous decline.
The work looks like administration, and its mistakes are expensive. Open a file marked confidential and your own scientists may be accused of using it years later. Decline a molecule you asked to see again, and you lose a deal and a reputation together. Sit on a pitch for three weeks and the sender concludes you are not serious, and takes it to your competitor. What follows explains how to avoid each of these, with the numbers that exist and a plain note where none do.
One pitch, from the sender's outbox to a signed licensing deal
The pitch arrivesThrough a portal, an inbox, a banker or a meeting. Each channel carries a different document and a different level of detail.
Triage reads, scores and answers itHours of expert time at most, in the first days. Keep it closed if marked confidential, find any earlier pitch, score fit, route or decline, and reply.
A reviewer forms a viewA therapeutic-area scientist reads the cited summary and asks for a call, more data, or nothing further.
Both sides sign a confidentiality agreementOnly now does confidential data move, usually into a data room (a secure online folder), for weeks or months of detailed checking, called diligence.
Term sheet, then contractThe deal itself: a short paper of main terms, then the full contract. One biotech licensing lead says a license from a large company took "the better part of a year" to complete.3
Step 2 is the subject of this guide. Steps 4 and 5 are covered only where triage touches them.
Most pitches end at the first reader, and three more facts about the front door
Few pitches reach diligence
One royalty investor, a firm that funds drugs in return for a share of their sales, disclosed its 2023 funnel: about 400 opportunities reviewed, 120 confidentiality agreements, 90 in-depth reviews and nine deals.4 It is the clearest public funnel we could find, and it comes from a financier, since no large drug company publishes one.
The first rule is about what you must not read
Partner pages ask for non-confidential material. One portal explains why: it removes the risk of jeopardizing the recipient's own research, and protects the intellectual property of both sides.5
Many a no means come back later
That same investor tells companies to come back in a year or two, then checks whether management delivered. About 40% of the $15 billion it deployed from 2020 went to repeat deals.4
The slow part is the queue
At 450 pitches a year and 1.5 hours each, the work adds up to under three hours a business day. In the same illustrative example a reply takes three weeks, because the pitch spends nearly all that time waiting.
Search and evaluation, non-confidential deck, CDA, search criteria: the terms you meet first
Search and evaluation
The BD function that finds drugs at other companies, known as assets, and judges them. Often shortened to S&E; job titles read "Director, Search & Evaluation".
Non-confidential deck
A short overview of a drug that the sender is content to show without a contract: mechanism, stage, key data, patents and the ask.
CDA
Confidential disclosure agreement, the pharma name for a non-disclosure agreement. It must be signed before confidential data moves.
Search criteria
What a therapeutic area has said it wants: priority diseases, evidence, kinds of drug and rights. A pitch is scored against the approved version.
What search and evaluation decides first: five answers a pitch can get
In shortTriage gives one of five answers: route to a reviewer, take a second look, ask for more, decline, or hold for legal. It decides who spends time on what; the deal decision comes later, from others. The pool it draws from is enormous, and the share that survives is small.
The pipeline of medicines in development worldwide numbered about 22,940 in Citeline's 2026 count, the first fall since the mid-1990s.6 Many of those assets have owners who would listen to an offer. Search teams go looking for some of them. Others arrive on their own, and those are the inbound flow. A GSK business development leader told the same 2024 panel, "It's pretty rare we don't know about something".1 So a pitch often lands on someone who has heard of the asset already and cannot find what the company concluded last time.
One investor's published funnel: 400 looks, 120 agreements, nine deals
A royalty investor's opportunities in 2023. The closest public analogue; no large drug company publishes its own.
Read that funnel carefully. Most of the drop, 280 of 400, happened before anyone signed anything, on the strength of a story told in an hour-long call. That is the triage stage. A company that treats it as clerical has handed its largest decision to whoever had time that week.
Route, second look, ask for more, decline, hold: what each answer asks of the reader
Route
Send to the reviewer
The pitch fits what the area asked for. It goes to a named scientist with a summary and reasons, and a clock starts for the reviewer's view.
Second look
Read it again
The score sits in the middle. A senior reader decides, often against something the score cannot see, such as a new competitor.
Ask for more
Name the missing piece
A non-confidential summary of the clinical data, the planned trial design, or patent family numbers. A specific ask gets a specific answer.
Decline
Say why, kindly
The reason is real and about fit: outside the priority list, too early, a crowded mechanism. The door stays open with a stated condition.
Hold
Stop before reading
A file marked confidential waits unopened for legal, whatever its promise. Only the receipt is logged.
How many conference meetings feed the partnering inbox
Partnering conferences show how the flow has grown. BIO-Europe Spring recorded 4,001 one-to-one meetings in 2007 and 17,338 in 2026, and its peak was 19,340 in 2024.7 The BIO International Convention reports 66,308 partnering meetings for 2025.8 Each meeting can leave a page of notes on someone's laptop, and those notes are pitches too.
One conference's partnering meetings more than quadrupled in two decades
BIO-Europe Spring one-to-one meetings; 2020 to 2022 were digital
What nobody publishes. We found no public figure for how many pitches a large drug company receives each year, what share it declines at first read, how fast it replies, or how many it sees twice. Panel remarks say "thousands"; a vendor's dashboard says whatever its sample says. Count your own for one quarter.
03 · Rules and dates
The law around an inbound pitch, and what changed for China-origin assets in 2025 and 2026
In shortNo regulator writes rules for triage. Trade secret law, securities law, contract law, merger filings and national security rules all reach it anyway. The news is Treasury's October 2026 proposal to bring biotechnology into its outbound investment program, which restricts American investment in sensitive Chinese technology. Law firms read it as leaving pure licensing outside, for now. It is a proposal, comments close December 7, 2026, and a bill would go further.
The rules around a licensing pitch have kept moving since 2022, fastest in 2026
Feb 10, 2022FDA committee votes 14 to 1
Against a drug tested only in China.
Apr 5, 2024Shadow trading verdict
A BD director found liable.
Dec 18, 2025BIOSECURE and COINS enacted
Both in the FY2026 defense act.
Mar 19, 2026Old merger form returns
Fifth Circuit denies a stay.
Jun 2 and Aug 6, 2026BINSA introduced
House, then Senate. Would reach licensing.
Oct 26, 2026Treasury proposal published
Biotechnology added to outbound rules.
Dec 7, 2026Comments close
Treasury's deadline.
Dec 18, 2026OMB list due
The Office of Management and Budget's list of biotechnology companies of concern.
A secret must be guarded by "reasonable measures". Independent derivation is lawful, so a company accused of copying needs to show its team never read the file.16
In force since 2016
Regulation FD (Fair Disclosure), 17 CFR 243.100
A public company that gives material nonpublic information to a person who "expressly agrees" to keep it confidential falls outside the public-disclosure duty.17 A public biotech's pitch may carry such information.
In force
SEC v. Panuwat
A jury found a biopharma senior director of BD liable for trading a third company's options on deal news.10 Your restricted list, the companies staff may not trade, should cover what triage sees.
Verdict April 5, 2024; Ninth Circuit heard argument June 11, 2026; no opinion found18
SIGA v. PharmAthene (Delaware)
A license term sheet footed "Non Binding Terms" still supported expectation damages once the parties had agreed to negotiate in good faith on it and one side then acted in bad faith.19 A reply letter should not float terms.
Delaware Supreme Court affirmed $113 million in damages, December 23, 2015;19 with pre-judgment interest the judgment was about $195 million20
Hart-Scott-Rodino (HSR) Act, 16 CFR 801.2(g)
A license moving all commercially significant rights to a pharmaceutical patent in a therapeutic area or indication counts as buying an asset, even if the licensor keeps co-rights.21 A large exclusive ask may need a merger filing.
Minimum threshold $133.9 million from February 17, 2026. A court vacated (set aside) the expanded form; the earlier form is operative; appeal pending12
BIOSECURE, FY2026 defense act
A procurement rule. Federal agencies may not buy biotechnology equipment or services from listed companies, or contract with firms that use them to perform the contract, and federal loan and grant money may not pay for them. The section does not mention licensing.11,22 Read the manufacturing slide with this in mind.
Law since December 18, 2025. The first list from the Office of Management and Budget (OMB) is due within a year, by December 18, 2026; no list found on November 3, 2026. Some earlier contracts get up to five years11,23
Comprehensive Outbound Investment National Security (COINS) Act rules, proposed 31 CFR Part 85124
Would restrict US investment in Chinese companies that use biological systems to produce or modify pharmaceutical compounds, among other biotechnology activities.15 Law firms read a pure license as outside it; an equity stake or joint venture may not be.24,25
Proposed, 91 FR 67396, October 26, 2026. Comments to December 7, 2026; one firm expects a final rule by early 202724
Biotech Investment National Security Act (BINSA), S. 5316 and H.R. 9102
Would add biotechnology to the outbound program and add "licensing a prohibited technology from a covered foreign person" to the transactions it covers.13,14
Introduced June 2 (House) and August 6, 2026 (Senate), and referred to committee; no further action found13,14,26
21 CFR 314.106(b)
FDA may approve on foreign data alone only if the data fit US patients and practice, the investigators are of recognized competence, and the data can be accepted or verified.27
In force. House members asked FDA in August 2026 to go further; no FDA reply found28
What Treasury's October 2026 proposal does and does not say about licensing
Two quick readings of this proposal are both wrong: that biotechnology sits outside the outbound rules, and that licensing from China is now restricted. Treasury's proposed rule, published October 26, 2026, does add biotechnology to the outbound program. It covers using a biological system to produce or modify, among other things, "a pharmaceutical compound", including small molecules, vaccines, cell and gene therapies and monoclonal antibodies.15
We read the proposal's definitions and found no category for licensing as a transaction. Law firms agree, in careful words, and their reading turns on the shape of the deal.
Pure license
Read as outside the proposal
Goodwin says the rule "does not govern pure licensing-only transactions".24 Holland & Knight reports a Treasury official's statement that the proposal does not include licensing agreements by US drug companies with Chinese counterparties.25 Foley Hoag says it "does not categorically prohibit" such licensing.29
License plus equity or a joint venture
May be caught
Goodwin warns that "many licensing transactions may be captured" when they come with equity or a joint venture.24
If BINSA passes
Licensing itself is added
The bill would add "licensing a prohibited technology from a covered foreign person" to the transactions the program covers.13,14
Three things could change this. Treasury is taking comments to December 7, 2026, and asks whether and how "pharmaceutical compounds" should be "more precisely scoped to focus on advanced or frontier technologies".15 BINSA would reach licensing directly.13,14 And a committee chair said on October 23, 2026 that he would work on how the final rule treats dependence on Chinese biotech assets.30 A separate draft executive order on Chinese licensing deals was reported in September 2025, and a White House spokesperson denied "actively considering" it; we found no signed order.31
What this means for a triage reader on a Tuesday
Counsel decides these questions. Triage records the facts that let counsel decide them quickly: where the company is domiciled, who owns it, who manufactures the drug, where the human data were generated, and whether the ask includes equity or a joint venture. A field left blank here becomes a week lost later.
For a China-origin asset, the same record feeds the reviewer's scientific question. FDA's advisory committee voted 14 to 1 in February 2022 against a drug supported by a trial run only in China, and said the sponsors should run trials reflecting US patients.9 A pitch whose data come from one country is a pitch with a question attached.
Rules that do not govern this work. Triage is a business decision, with no regulated product record in it, and several familiar rules stop short of it. FDA's January 2025 draft guidance on AI says it does not address AI used in drug discovery or for "operational efficiencies" that do not affect patient safety, drug quality or the reliability of study results.32 21 CFR Part 11 covers electronic records kept under agency record requirements and electronic filings to the agency, and a pitch register is neither.33 Part 11 becomes relevant only if a record later moves into a regulated file.
04 · What arrives
Portal form, BD inbox, banker teaser, meeting notes: what each channel gives the first reader
In shortA pitch comes in four shapes, and they differ in completeness and in urgency. A portal form is tidy and thin. A deck is full and unstructured. A banker's teaser is short and comes with a bid date. Meeting notes are half a page written from memory. A reader's first task is to turn all four into the same set of fields, and to leave a field empty when the pitch did not say.
Partner pages tell senders what to send, in few words. One large device and diagnostics company asks for "nonconfidential information" and points to a partnering portal.34 A drug company's page says it assesses every project against one published framework so it can give "consistent, objective feedback".35 The response time, on every page we could read, goes unstated.
Decks carry the data, portals carry the fields, and only bankers carry a deadline
How often each channel gives the reader what triage needs. Our judgment from deal practice; score your own sample.
RarelyPartlyUsually
MechanismStage and dataPatentsThe askA dateNon-confidential deckUsuallyUsuallyUsuallyPartlyRarelyPortal formUsuallyPartlyPartlyPartlyRarelyBanker's teaserPartlyPartlyPartlyUsuallyUsuallyMeeting notesPartlyRarelyRarelyPartlyRarelyCold emailPartlyRarelyRarelyRarelyRarely
Illustrative · replace with your own numbers
Show the numbers
Mechanism
Stage and data
Patents
The ask
A date
Non-confidential deck
Usually
Usually
Usually
Partly
Rarely
Portal form
Usually
Partly
Partly
Partly
Rarely
Banker's teaser
Partly
Partly
Partly
Usually
Usually
Meeting notes
Partly
Rarely
Rarely
Partly
Rarely
Cold email
Partly
Rarely
Rarely
Rarely
Rarely
Eleven fields that turn any pitch into one line of a register, the team's running list of pitches
Teams differ on the details, and most registers converge on the same short list. The discipline that matters is the citation. Each value carries the slide or page it came from, because the reviewer will not trust a summary she cannot check, and the company may be misquoted otherwise.
Field
What to capture
The usual trap
Asset
Code and any other name in the deck
A new code for an old molecule
Company
Legal name, domicile, former names
A rename mentioned once, on slide 2
Modality
Antibody, oral small molecule, cell therapy
An area that excludes this modality this year
Mechanism
Targets, in the deck's own words
Marketing language where a target name belongs
Indication
First disease, with severity and line of treatment
A long list of possible diseases
Stage
Trial phase completed, as stated
"Phase 2 ready" read as Phase 2
Data highlights
Endpoint, numbers, patients, control
A percentage with no denominator
IP (patents)
Patent type, status, territory, last expiry
"Filed" recorded as "granted"
The ask
Rights, territory, structure, date
A bid date buried in a process letter
Contact
Name, role, banker or principal
A familiar person on a new email domain
Marking
Confidential or not, and where it says so
A stamp on one page only
05 · The confidential boundary
Why a file marked confidential must stay closed until a CDA is signed
In shortA large company's scientists may already be working on something close to what a stranger sends. If they read the stranger's secret, a later patent or program can be challenged as copied. So the check comes before reading, it looks only at the cover and the file labels, and it logs a receipt that proves the file stayed shut.
Put yourself in the recipient's position. Your oncology group has an unpublished idea for a new cancer drug. An email arrives with an attachment called "confidential data package", describing something similar. If anyone opens it, you now have two problems. The sender may later say you took its idea, and you may have to prove you did not.
The Defend Trade Secrets Act offers a defense, since independent derivation is not an improper means of acquiring a secret.16 That defense is much easier to run if you can show nobody read the file.
One consumer company's portal states the logic plainly: taking only non-confidential material "eliminates the risk of jeopardizing" its own research, and a confidentiality agreement comes only if the overview is of interest.5 Drug companies follow the same order, and a reply to a confidential sender says so, offers a CDA, and asks for a non-confidential summary in the meantime.
The check happens before anyone reads, and a marked file never reaches a reviewer
The path of a file through a well-run front door
1Cover and labels only
The reader sees the email text and file names. The attachment stays shut.
Triage readerMinutes
2Marked confidential
Hold the file. Log name, size, digital fingerprint and time, and nothing else.
Triage readerSame hour
3Legal is told
Counsel owns the file from here. Draft the reply that asks for a CDA first.
BD counselSame day
4Sender chooses
Sign a CDA, send a non-confidential summary, or take the file back.
SenderDays
5Return or delete
On request, the file goes back unread, and the log proves it.
BD counselOn request
Illustrative · replace with your own numbers
Show the numbers
Step
What happens
Who
Time
Cover and labels only
The reader sees the email text and file names. The attachment stays shut.
Triage reader
Minutes
Marked confidential
Hold the file. Log name, size, digital fingerprint and time, and nothing else.
Triage reader
Same hour
Legal is told
Counsel owns the file from here. Draft the reply that asks for a CDA first.
BD counsel
Same day
Sender chooses
Sign a CDA, send a non-confidential summary, or take the file back.
Sender
Days
Return or delete
On request, the file goes back unread, and the log proves it.
BD counsel
On request
Four ways the confidential boundary fails at a real front door
The mark sits inside
A deck with no label on its cover, and "Confidential" stamped on page 7. A person opens the file to find out. Ask senders to say so in the email, and check every page label a tool can read without displaying the content.
A colleague forwards it
A scientist receives a deck directly from an old friend and passes it to BD. It has now been read, by someone inside. Train the whole company, and log how each file arrived.
The template says confidential
A law firm footer on every page of what is plainly a public overview. Hold it anyway and ask. A day lost costs less than a wrong guess.
The meeting wandered
Notes from a conference table record something the speaker asked you to keep to yourself. Decide who writes those notes, and what they do when this happens.
What a CDA should say before a pitch can move on to data
Once both sides want to go further, counsel's questions are about scope and memory. How long does the obligation last? Does it cover the fact of the talks? And is there a residuals clause, which lets the recipient keep using what its people remember? Farrer & Co, a law firm, notes that such clauses are common in agreements written by large technology and pharma companies, and warns that they can let a recipient use remembered information at will.36
A small biotech should read that clause first, and a large company should know its own form contains it. Term lengths vary by deal; we found no public benchmark for how long these agreements take to negotiate, so measure yours from request to signature.
06 · Scoring fit
How a fit score works on an inbound pitch: six points, worked through with numbers
In shortA fit score asks one question: does this pitch match what this area said it wants, today? It is a weighted sum, and the arithmetic is simple. The score sorts a queue, and valuing the asset stays with the reviewers. It hides its own assumptions unless each point carries a reason and the criteria carry a version.
Here is a common way to build one. Choose a handful of points and give each a weight that sums to 100. For each pitch, a reader judges how well it meets each point, from 0 to 1, and multiplies. Take the example from the top of this guide, scored against an immunology area's criteria:
fit = Σ (weight × how well the pitch meets the point) = 30×0.93 + 20×0.80 + 20×0.80 + 10×1.00 + 10×0.90 + 10×0.70 = 85.9, shown as 86
QH-1187 loses most of its points on differentiation and human evidence
Points lost out of 100 at each scoring point, on the fictional example; total lost 14.1
Differentiation at launch (weight 20)4
Stage and human evidence (weight 20)4
Competitive space (weight 10)3
Strategic fit (weight 30)2.1
Rights and IP (weight 10)1
Modality in scope (weight 10)0
Fictional example from this guide
Show the numbers
Item
Value
Differentiation at launch (weight 20)
4
Stage and human evidence (weight 20)
4
Competitive space (weight 10)
3
Strategic fit (weight 30)
2.1
Rights and IP (weight 10)
1
Modality in scope (weight 10)
0
Next, cut-offs. A team might route at 65 or above, take a second look from 50 to 64, and decline below 50. Those lines are choices, and they should be tested against history. Score last year's pitches on the current rule and see which of them the reviewers kept. If half of what they kept scored under 65, the weights are wrong, whatever they look like on paper.
Six points that separate a fit score from a gut feeling
Weight 30
Strategic fit
Is the disease on this area's priority list?
Weight 20
Differentiation at launch
Better than the standard of care, the usual treatment, expected when it would launch, which is seldom today's.
Weight 20
Stage and human evidence
Proof in people of mechanism or effect.
Weight 10
Modality in scope
A kind of drug the area has said it will take on this year.
Weight 10
Rights and IP
Territory on offer, patent status and patent life.
Weight 10
Competitive space
How crowded this mechanism already is.
These six and their weights are one reasonable set, used in this guide's example. Yours should reflect your own strategy.
Reading a small study without being fooled by it
A deck's lead number deserves one quick test. QH-1187's slide reports clinical remission at week 12 in 33% of treated patients (6 of 18) against 7% on placebo (1 of 14). Those are encouraging numbers from a small study. A 95% confidence interval gives the range of true rates the data are consistent with, and here the two ranges overlap. Fisher's exact test asks how likely a gap at least this big would be if the drug did nothing.
16–56%
about the range for the treated group, 6 of 18 in remission.
Wilson method. Our arithmetic, fictional figures
1–31%
about the range on placebo, 1 of 14. The two overlap.
Wilson method. Our arithmetic, fictional figures
0.10
about the two-sided p from Fisher's exact test.
Our arithmetic, fictional figures
The result earns the deck a reviewer's attention, and it is too thin to support a price.
The same care applies to the rest of the clinical data on a slide: how many patients, compared with what, measured when, and chosen how. A first reader records those four things and leaves the judgment to the reviewer.
What a phase is worth: published success rates, by therapeutic area
Drugs pass through three trial phases in people. Phase 1 looks at safety and dose in a small group, Phase 2 starts to test whether the drug works in people with the disease, and Phase 3 tests that in a much larger group.37
A fit score says nothing about the odds of getting through them, so readers should know the base rates. BIO, Informa and QLS Advisors studied 9,704 development programs from 2011 to 2020. Across all diseases, 7.9% of drugs entering Phase 1 reached approval, and Phase 2 was the hardest step, at 28.9%.38 Multiply the published transition rates and you get the chance from the start of Phase 2 to approval.
From Phase 2, an autoimmune drug's odds are nearly twice an oncology drug's
Chance of approval from the start of Phase 2, multiplying the published Phase 2, Phase 3 and filing rates, 2011 to 2020
What a median upfront asks you to believe about an early-stage drug
Now put odds and price together. J.P. Morgan's report on DealForma data gives median upfront cash and equity for big pharma in-licensing in 2025: $125 million at Phase 1 on 14 deals, $180 million at Phase 2 on 8 deals and $240 million at Phase 3 on 6 deals.39 Divide each by the published chance of approval from that phase, and you get the value the drug must be worth on approval, in present value after all remaining costs, just to repay the upfront.
A median Phase 1 upfront needs a drug worth about $1.6 billion on approval just to break even
2025 median upfront ÷ chance of approval from that phase. Ignores milestones, royalties, trial costs and time, all of which raise the bar.
This model belongs to the reviewer and the valuation team, who use risk-adjusted net present value: a drug's future cash, discounted and weighted by its odds. A triage reader needs the sense of scale, so that an unrealistic ask is recorded as such. The upfront is usually a small part of an announced deal: 6% of announced licensing value in 2026 to date, on J.P. Morgan's figures.39 The example's $75 million on $1.3 billion is 5.8%.
07 · Repeat pitches
The same molecule under a new name: how to recognize a re-pitched asset
In shortAn asset can come back with a new code, a new company name, a banker in front of it or a new disease. Each change breaks a search on the name. Asset identity lives in things that are harder to change: the targets and format, the manufacturer, the contact and the company's own history. A match should state its reasons, bring back the earlier decision and what has changed, and wait for a person.
Companies rename themselves after a funding round or a merger. Assets get a new code when a program moves to a new owner. A banker's teaser may hide the company's name until a CDA is signed. A molecule declined for one disease returns for another. These are ordinary business changes, and the sender may not know you saw it. What suffers is your own memory: a reviewer reads it again from the beginning, or a different reviewer says something different, and the company notices.
The earlier answer matters more than most teams assume. The royalty investor whose funnel opened this guide describes deliberately telling companies "it's too early. Why don't we meet in a year or two", then checking whether management did what it said.4 A watch list is a promise to remember, and it pays to keep it. When the condition you named has been met, the reply can say so in a line.
Target and format, manufacturer and people survive a rename; the code does not
How reliable each clue stays when an asset comes back changed. Our judgment; test it on your own repeats.
LostWeakHolds
New codeRenamed companyBanker in frontNew diseaseAsset codeLostWeakWeakHoldsCompany nameHoldsLostLostHoldsTarget and antibody formatHoldsHoldsWeakHoldsManufacturer and cell lineHoldsHoldsLostHoldsContact personHoldsHoldsLostHoldsPatent familyHoldsHoldsWeakHoldsDiseaseHoldsHoldsHoldsLost
Illustrative · replace with your own numbers
Show the numbers
New code
Renamed company
Banker in front
New disease
Asset code
Lost
Weak
Weak
Holds
Company name
Holds
Lost
Lost
Holds
Target and antibody format
Holds
Holds
Weak
Holds
Manufacturer and cell line
Holds
Holds
Lost
Holds
Contact person
Holds
Holds
Lost
Holds
Patent family
Holds
Holds
Weak
Holds
Disease
Holds
Holds
Holds
Lost
Three kinds of match that deserve three different answers
What came back
What the reader does
What the sender should hear
Same asset, new data, condition met
Attach the earlier note. Route to the same reviewer with what has changed.
"We remember the conversation, and this is the data we hoped to see."
Same asset, nothing new
Decline for the same reason, and record that it was seen again.
The same answer as last time, plus what would change it.
Same target class, different asset
Show the earlier decisions on the class. A reviewer who declined three in a year has a view.
A real reason, such as a crowded mechanism.
No public figure exists for how often assets are re-pitched. Take your last 100 pitches, search each by target and company history, and count.
08 · The reply promise
Keeping a reply promise: how, in an illustrative queue, 90 minutes of work takes three weeks
In shortReplies are late because pitches wait. Queue arithmetic on illustrative inputs shows it: at a 16.5-day median, about 30 pitches sit open at any moment, while the reading itself takes under three hours a business day. Shortening the wait means shortening the queue, and that means setting a clock on every pitch, seeing it before it runs out, and having the answer drafted.
A sender who hears nothing draws a conclusion. As one deal adviser told the 2024 panel, silence "doesn't mean they don't like you; it just means they haven't been able to get to you yet".1 A founder cannot tell the difference, and in the time you take, a rival may reply. We found no independent survey of first-reply times, so this section works with arithmetic you can check, using illustrative inputs. It rests on Little's law, a standard queueing rule: the number waiting equals the arrival rate times the wait.
pitches open at any moment = arrivals per business day × days each one waits 450 pitches ÷ 250 business days = 1.8 a day 1.8 × 16.5 days ≈ 30 open · 1.8 × 2.5 days ≈ 4.5 open · work: 1.8 × 1.5 hours = 2.7 hours a day
The same work, one-seventh of the waiting pile
Open pitches at a given median first reply, by Little's law, at 450 pitches a year (illustrative)
16.5-day median2.5-day median
Pitches waiting for a first reply at any moment30 open pitches4.5 open pitches
Illustrative · replace with your own numbers
Show the numbers
16.5-day median
2.5-day median
Pitches waiting for a first reply at any moment
30 open pitches
4.5 open pitches
Counting business days without an argument
Write down how you count. A pitch that arrives on September 22, 2026 with a 10-business-day promise is due on October 6: count the 23rd as day 1 and skip the weekends. If it gets its reply on October 7 it is one day late, and the letter should say so.
A pitch that arrives September 22 is due October 6, and a reply on October 7 is one day late
A 10-business-day promise, counted on the dates of this guide's fictional example
Sep 22The pitch arrives
The count starts on the next business day.
Sep 23Day 1
Wednesday.
Sep 26 to 27, Oct 3 to 4Two weekends
Skipped.
Oct 6Day 10
The reply is due.
Oct 7One day late
The letter says so.
Fictional example from this guide
Show the numbers
When
What
Sep 22
The pitch arrives
Sep 23
Day 1
Sep 26 to 27, Oct 3 to 4
Two weekends
Oct 6
Day 10
Oct 7
One day late
Decide whether you count your holidays or the sender's, since Golden Week in China and August in Europe both shift what a reasonable answer looks like. Report the share answered on time alongside the median: the median hides the long tail, and the tail is where the angry emails come from.
A reply promise has a second clock inside it. Once a pitch is routed, the reviewer owes a view, perhaps in 5 business days. Separate the two. If a reviewer has a pitch for three weeks, the first reply can still go out on day 2, truthfully: thank you, this fits, here is who will look at it and when you will hear. An acknowledgment is an answer, as long as it is honest about what comes next.
What a good first reply says, and what it never says
Next step
Route with a name
Says who will review it, and proposes a science call. Restates that nothing confidential should come before a CDA.
Decline
Give the true reason
About fit, and specific: gene therapy is out of scope this year, human data are needed. Invites a return on stated terms.
CDA request
Explain the closed file
Says the attachment has not been opened and can be returned or deleted, and asks for a non-confidential summary.
Never
Terms or hints of terms
No numbers, no "we would be prepared to". In SIGA v. PharmAthene, a paper footed "Non Binding Terms", a promise to negotiate on it and a finding of bad faith ended in $113 million of damages.19
On SIGA, the two figures in circulation count different things. The opinion's $113 million is the lump-sum expectation damages.19 SIGA's own annual report puts the judgment at about $195 million, including pre-judgment interest to January 15, 2015, and says it paid $217 million in all once post-judgment interest ran.20 One law firm's note calls the whole $195 million expectation damages.40
09 · The market
Why inbound licensing pitches keep growing: record deal value, and half the big upfronts from China
In shortLicensing is near a record. Announced biopharma licensing reached $274.3 billion in 2025 and $221.1 billion through September 2026. China-origin assets are 51% of big pharma deals with $50 million or more up front in 2026 to date. Large companies have a reason to look, and more senders, in more languages and formats, are writing to them.
Announced licensing value set a record in 2025, and 2026 is already at 81% of it
Biopharma R&D licensing, announced value in $ billions, rounded; 2026 through September 30
Definitions matter here, because the headlines disagree. J.P. Morgan's 18 deals in 2026 to date, with upfronts of about $5.8 billion on its chart ($5.7 billion in its text), cover large-cap buyers only.39 A wider count cited by Arnold & Porter, from Reuters, puts all cross-border licensing with Chinese biotechs at a record $137 billion in 2025, against $13.9 billion in 2021.23 A trade report puts the average upfront on China licensing deals at $172 million in 2026, up from $52 million in 2022, and names no data source.42 They measure different things.
For a front door, this means a new sender mix: decks translated from Chinese, companies a reader has never heard of, patents granted in China and pending in the US, and data from trials in one country. It also means the people asking for a reply are moving quickly, since competing buyers are reading the same deck. One benchmark of asset-finding tools, written by a vendor, was built around this problem: it mined mostly non-US assets from non-English sources.43
What big pharma pays up front at each stage
Big pharma's median upfront climbs with the stage, on few deals
In-licensing by big pharma, median upfront cash and equity, 2025, with the number of deals
The 2026 medians through September are higher at Phase 2 ($363 million) and Phase 3 ($450 million), on two and three deals, so we chart 2025. J.P. Morgan itself says those 2026 medians "reflect limited activity".39
10 · What goes wrong
How inbound triage fails: the opened file, the second answer, the missed bid date
In shortMistakes at the front door are cheap to make and hard to see, because a declined pitch leaves no trace in anyone's results. The common ones are lost pitches, stale criteria and a slow reply. The rare ones, an opened confidential file or a wrong decline on a good asset, can cost far more than the whole team. Nobody publishes error rates, so plot your own.
Most frequent errors are cheap and the costliest are rare, so they need different controls
Our judgment of how often each happens and what it costs; place your own after a sample audit
Cost when it happens →
Build a hard control
Automate first
Accept and sample
Fix the process
Opened fileWrong declineTwo answersMissed bid dateStale criteriaLate replyMisread field
How often →
Illustrative · replace with your own numbers
Show the numbers
Item
How often (0–1)
Cost when it happens (0–1)
Opened file
0.12
0.70
Wrong decline
0.25
0.54
Two answers
0.70
0.60
Missed bid date
0.15
0.17
Stale criteria
0.55
0.30
Late reply
0.80
0.22
Misread field
0.65
0.12
Failure
How it happens
How you would find out
The pitch nobody owned
It came to a named person who left or was traveling, or sat as a note from a conference.
A sender chases you, or announces a deal with someone else
Scoring on old criteria
The area changed its priorities in June and the reader's spreadsheet did not.
Compare the version used on each score with the approved one
The missed bid date
"First bids Nov 2" sits in a process letter, and the pitch waits with the others.
List every banker's date you passed last year
A misread status
"Composition of matter filed" recorded as granted; "Phase 2 ready" recorded as Phase 2.
Re-read 25 register rows against their decks
A reply that implies interest
A warm template read as an offer, or terms in an email thread.
Have counsel read 25 sent replies
The wrong no
A busy reader pattern-matches to an unfashionable mechanism. Nobody ever checks.
Review declines from three years ago against later public deals
The wrong no costs most, and nobody counts it
A bad deal shows up in a write-down. A good deal you declined shows up only as a competitor's press release, years later, and no internal report will ever connect the two. The authors of an asset-scouting benchmark say that missing one qualifying asset "can mean losing a top partnering or acquisition opportunity worth billions of US dollars", and they have a product to sell, though the logic holds.43
The honest test is a look back. Each year, take your declines from three years ago, check which went on to a public deal or a Phase 3 trial, and read why you said no. If the reason still stands, good. If it reads as "nobody looked", you have found your cost.
Deal pressure runs both ways. One panelist at the 2024 session warned companies against creating "false competitive tension", and another added "Never lie".1 A reader who records what a banker claims, as a claim, keeps the reviewer from inheriting the urgency.
11 · AI and its limits
What AI can do with a pitch deck, what the rules say about it, and where it stops
In shortReading a deck into fields, finding an earlier match, scoring against written criteria and drafting a reply all suit AI, with a person deciding. The rules most people worry about mostly do not reach this work. The real risks are the confidential boundary, a made-up citation, and instructions hidden inside a stranger's file.
Software can already read a slide deck faster than a person and put each fact in a field. What it can do reliably is a narrower question, and public evidence is thin.
The most relevant study we found is a February 2026 benchmark of tools for finding drug assets, written by the company behind the top-scoring tool. Its purpose-built tool scored an F1 of 79.7%, a measure that balances finding every right answer against avoiding wrong ones, against 56.2% for the best general research tool and 26.9% for the lowest, on a test set of 22 query-and-asset pairs.43
A purpose-built tool beat general ones at finding assets, on its own builders' test
F1 score on 22 query-and-asset pairs. The authors built the top tool; no independent replication found.
That benchmark tests outbound search. Inbound triage is an easier and different job: the document is in front of you, so the test is whether each field matches its page. Nobody has published error rates for it. So measure on your own past pitches, against what your reviewers actually decided.
Which AI rules reach an inbound pitch, as of November 2026
Rule
Does it reach triage?
Status
FDA draft guidance on AI for regulatory decisions
No. It does not address AI in drug discovery or for operational efficiencies, such as internal workflows, that do not affect patient safety, drug quality or the reliability of study results.32
Draft, January 2025; FDA's page still says draft
FDA Computer Software Assurance
No. Its scope is software in medical device production or quality systems.44
Final, February 2026
Draft EU GMP (good manufacturing practice) Annex 22
No. It concerns AI in manufacturing, where its draft says generative models should not be used in critical applications.45
Draft; EudraLex Volume 4 lists no Annex 22
EU AI Act
Scoring business pitches is not on its face a high-risk use; take counsel's view. Its general duties still apply.
Regulation (EU) 2026/1744 moved Annex III rules to December 2, 2027 and Annex I rules to August 2, 202846
Three limits that need a person, whatever the tool
A stranger's file is untrusted input
OWASP lists prompt injection first among risks for large language models, and notes the indirect kind arrives through "external sources, such as websites or files".47 A deck could carry hidden text telling a reader to score it highly. So a person checks every score that decides something, and each point must cite visible text.
A cited field can still be wrong
A citation lets a reviewer check a value. It proves nothing until someone does. Track how many values reviewers correct, by field, and treat a low-confidence field as unread.
Where the deck goes matters
A non-confidential deck may still be unwelcome training data. Ask where it is stored, who can read it, whether any model learns from it, and how you delete it when the sender asks.
12 · How teams do it today
Who answers a partnering pitch today: S&E lead, area reviewers, BD counsel and BD operations
In shortA small team of well-paid experts spends part of its week as a sorting office. A pitch passes between the S&E lead, a therapeutic-area reviewer, BD counsel and BD operations, usually by email, with a spreadsheet or a CRM (the contact and deal database sales teams use) behind it. Most of the time goes to reading and logging, and the elapsed time goes to waiting.
S&E lead to BD operations: four roles around one pitch
SE
Search and evaluation lead
Owns the inbound flow, confirms routing and signs replies. Also has outbound searches and live deals.
Cares about: every sender getting an answer, even when it is no.
TR
Therapeutic-area reviewer
A scientist or physician with a day job in research, asked to give a view on pitches in that field.
Cares about: fewer, better pitches, and knowing what the company said last time.
BC
BD legal counsel
Owns CDAs, the confidential boundary and the wording of anything that could be read as a commitment.
Cares about: nobody opening a marked file before a CDA.
BO
BD operations
Keeps the register, the routing rules, the reports and the service levels.
Cares about: seeing the late ones before they are late.
Five steps before a sender hears anything, and most of the days pass between them
A typical inbound path with no software support
1Pitch lands
Portal, inbox, banker or notes. Forwarded to whoever covers BD intake.
BD operationsDay 0
2Logged
Into a spreadsheet or CRM, when someone gets to it.
BD operationsDays 1 to 4
3Read and scored
The deck is read, the fields filled, the area's criteria consulted.
S&E leadDays 4 to 10
4Routed
Emailed to a reviewer, who has other work.
S&E leadDays 10 to 15
5Answered
A letter written by hand, or a template.
S&E lead, counselDays 12 to 20
Illustrative · replace with your own numbers
Show the numbers
Step
What happens
Who
Time
Pitch lands
Portal, inbox, banker or notes. Forwarded to whoever covers BD intake.
BD operations
Day 0
Logged
Into a spreadsheet or CRM, when someone gets to it.
BD operations
Days 1 to 4
Read and scored
The deck is read, the fields filled, the area's criteria consulted.
S&E lead
Days 4 to 10
Routed
Emailed to a reviewer, who has other work.
S&E lead
Days 10 to 15
Answered
A letter written by hand, or a template.
S&E lead, counsel
Days 12 to 20
Where an estimated 90 minutes on one inbound pitch go
Reading the deck and scoring it take more than half of a pitch's hands-on time
Minutes per pitch, estimated, for a pitch of ordinary length; time your own
Logging and marking checkReading and filling fieldsChecking for an earlier pitchScoring fitRouting and replying
Minutes per pitch1230121818
Illustrative · replace with your own numbers
Show the numbers
Logging and marking check
Reading and filling fields
Checking for an earlier pitch
Scoring fit
Routing and replying
Minutes per pitch
12
30
12
18
18
Four ways teams run the inbound flow: inbox and spreadsheet, CRM, outsourced scouting, partnering software
1 · Inbox and spreadsheet
Run by hand
A shared mailbox and a workbook, with a reader who knows the history.
Strength
Cheap, and the judgment stays close
Strain
Memory leaves when a person does
2 · CRM
A general system
Opportunities kept as records with fields and stages.
Strength
One record, and reporting
Strain
Someone still reads and types everything
3 · Outsourced
Scouts and advisers
A firm screens pitches, or searches on your behalf, and reports monthly.
Strength
Reach, and more eyes in new regions
Strain
Your criteria change faster than their brief
4 · Partnering software
Purpose-built tracking
Portals and evaluation workflows, now with AI reading.
Strength
Portal, workflow and audit trail in one
Strain
Value depends on who still does the reading
Part B · See it working
Botminds Partnering Opportunity Triage on one morning at Northwind Bio: 16 pitches, four channels, one fit map
Part A described the work without naming a product. This part shows how Botminds does it, on a fictional morning. Every company, person, asset and figure on these screens is sample data.
13 · One morning, start to finish
From an 8:41 am email to a signed reply: TV-3 lands on the fit map on day one
In shortIt is Wednesday, October 7, 2026 at Northwind Bio. Priya Ranvelle, Director of Search & Evaluation, has 16 pitches since September 22. Six AI agents read each one and place it on a map by fit and stage. She confirms each routing and signs each reply, beside the map.
Three pitches, three clocks, on the morning of October 7
Sep 22HM-208 arrives
Portal. Due October 6.
Oct 5QH-1187 arrives
Portal. Due October 19.
Oct 6Talwick's email
A file marked confidential. Held.
Oct 7, 8:41 amTV-3 arrives
Email from Dublin. Due October 21.
Oct 7TV-3's reply signed
First reply in one business day.
Oct 19QH-1187's reply due
Drafted and waiting for a signature.
Fictional example from this guide
Show the numbers
When
What
Sep 22
HM-208 arrives
Oct 5
QH-1187 arrives
Oct 6
Talwick's email
Oct 7, 8:41 am
TV-3 arrives
Oct 7
TV-3's reply signed
Oct 19
QH-1187's reply due
1
Every open pitch on one map, sized by the deal
Each bubble is a pitch. Across is fit against the area's search criteria; up is stage; size is the deal on the table, which is the company's ask or the median of comparable deals; color is the therapeutic area. Faded means closed.
Nine open pitches sit at 65 or more, with $11.2 billion on the table. One, PN-12, sits under 50. Above the map are three not on it yet: Talwick, held for legal, and the two new arrivals.
The fit map. Three zones across the top, the selected pitch on the right with its clock, its deal, its reviewer and its drafted reply.
2
The ring around HM-208 has turned red
Each ring is a reply clock. It fills as the 10-business-day promise is used, turns amber in the last two days and red when late. HM-208 from Hollowmere Therapeutics arrived on September 22 and its first reply was due October 6. It scores 74.
The draft says so: "Our apologies that this reply reaches you a day later than we promised."
One day late. Ten red segments, the $850 million deal, the reviewer and a draft that apologizes.
3
Priya clicks Read 2 new, and six agents take their turn
TV-3, a small-molecule eye implant lasting 6 months for wet age-related macular degeneration, reached the BD inbox at 8:41 am from Tamsin Vision in Dublin. The Confidentiality Check reads the cover note and file labels: non-confidential. The Pitch Reader takes 15 pages into 11 register fields, each with its page.
The Duplicate Finder checks 1,284 earlier pitches and finds no match above 60%. The Fit Scorer works against the eye care criteria, version 2.
Reading in place. Each agent's step in view, with what it found. The new pitch is marked as being read in the tray above the map.
4
TV-3 lands in the high-fit corner at 79
Phase 2 and fit 79 put it in the top right zone: high fit with human data. The deal on the table is $950 million, $70 million up front, from comparable deals. Eleven pitches now sit in the route zone, with $12.8 billion on the table, because WXB-17 landed at 67 as well.
The Router suggests Dr. Elena Vasquez, the eye care reviewer, and the Reply Writer has an acknowledgment drafted to Dr. Orla Fennick.
Where it landed. The new bubble carries a dashed selection ring, and its letter waits on the right.
5
Signed on day one of a ten-day clock
Priya reads the letter and signs it from the map. It thanks Dr. Fennick for the non-confidential overview, says the area is one Northwind is actively looking at and names who will review it. The clock now reads "replied in 1 day", and the audit trail records her signature.
Nothing goes to any sender until she signs.
Reply sent. One segment used of ten. The reviewer's own clock starts next.
QH-1187: the molecule from May, back with the data Dr. Chen asked for
The pitch in this guide's opening example is on the same map. Qingmere Biologics in Suzhou sent QH-1187 through the portal on October 5, an antibody blocking two inflammation targets, for moderate-to-severe ulcerative colitis, Phase 1b complete. Six agents read, checked and scored it in 38 seconds on this sample. The Pitch Reader turned its 14 slides into 12 fields: the usual 11 plus company history, because slide 2 says "Rivergate Bio is now Qingmere Biologics".
Each field, cited. Click a number and the deck opens at that passage. A low-confidence field shows amber.
The deck beside it. Highlights show where each field came from, including week-12 remission, 6 of 18 against 1 of 14.
Seen before. 94% similar to RGB-07, with four stated reasons, the reviewer's May note and what has changed since.
Fit 86, point by point. Against immunology criteria version 4, approved July 14, 2026. Each point carries a reason and a link.
Fit 86 is six scored points, and strategic fit carries the most weight
QH-1187 against immunology criteria version 4; points earned, of a 100-point total
Strategic fit (of 30)27.9
Differentiation at launch (of 20)16
Stage and human evidence (of 20)16
Modality in scope (of 10)10
Rights and IP (of 10)9
Competitive space (of 10)7
Fictional example from this guide
Show the numbers
Item
Value
Strategic fit (of 30)
27.9
Differentiation at launch (of 20)
16
Stage and human evidence (of 20)
16
Modality in scope (of 10)
10
Rights and IP (of 10)
9
Competitive space (of 10)
7
In May, Dr. Maya Chen wrote: "Interesting dual mechanism. Come back to us with Phase 1b data in ulcerative colitis." The match shows the same two targets and antibody format, the same manufacturing partner and cell line, the rename on slide 2 and the same contact on a new email domain. The Duplicate Finder lists these reasons and leaves the merging to a person. The drafted reply opens: "We remember RGB-07 from our conversation in May."
14 · A closed file and a kind no
Holding a confidential attachment unopened, and declining PN-12 with the true reason
In shortTwo answers matter as much as a yes. Talwick Therapeutics sent a file marked confidential, and it stays sealed: only its name, size, fingerprint and time are logged, while a CDA request goes to counsel. Pellucid Neuro's PN-12 scores 49, and its letter says why and what would change the answer.
Held at the boundary. The cover email is the only thing read. BD counsel sees the options on the right: approve the CDA request, ask for a non-confidential summary, or return it unopened.
Talwick's email of October 6 attached "CONFIDENTIAL — Talwick data package v3.pdf". The Confidentiality Check read the cover note and file label, and stopped. The register shows three facts from the email and leaves asset, mechanism and data empty on purpose. The setting behind this is locked by legal.
The CDA request. Says the file is unread, offers to return or delete it, and asks for a short non-confidential summary.
A true decline. Preclinical, with gene therapy out of scope for 2026. The letter calls it a decision about fit and invites the company back with first human data.
PN-12 is a preclinical gene therapy for Parkinson's disease from San Diego. It scores 49: 21 of 30 on strategic fit, 10 of 20 on differentiation, 2 of 20 on human evidence, 4 of 10 on modality, 8 of 10 on rights and 4 of 10 on competition. A person approves the letter or sends the pitch to Lena Ortiz, the neuroscience reviewer, anyway. Either choice lands on the audit trail, with the reason.
15 · Every screen
The screens behind the fit map: opportunity register, reviewer lanes, reply calendar, dashboard and search criteria
In shortBehind the map sit the screens each role lives in. The register is one searchable row per asset. Reviewer lanes show who holds what. The reply calendar shows every promise by the day it falls due. The dashboard shows the funnel. Settings hold each area's criteria, the weights and the clocks.
The opportunity register. One row per asset, 359 pitches this year, with search, area and status filters, export and a way to add a pitch.
Reviewers. A lane per reviewer and for counsel: what waits for routing, what each person holds, and the 5-day clock on their view.
The reply clock. Every promise by the day it falls due. HM-208 sits alone under Late; October 19 to 21 are next.
The year so far: from 16.5 days to 2.3, and 226 pitches that never took a reviewer's time
The dashboard, year to date. 359 received; 84% answered within 10 days; 503 hours returned, estimated at 1.4 hours a pitch.
Northwind's median first reply fell every month this year
Business days, on the sample data
051015202.3
JanMarMayJulSep
Fictional example from this guide
Show the numbers
Month
Median first reply
Jan
16.5
Feb
12
Mar
7.4
Apr
5.1
May
4.3
Jun
3.8
Jul
3.5
Aug
3.2
Sep
2.7
Oct
2.3
Of 359 pitches, 127 reached a reviewer and 20 reached a signed CDA
Northwind Bio, year to date, on the sample data
Received359
Read and scored353
Fit 65 or more136
Routed to a reviewer127
Next step agreed43
CDA signed20
Fictional example from this guide
Show the numbers
Stage
Count
Received
359
Read and scored
353
Fit 65 or more
136
Routed to a reviewer
127
Next step agreed
43
CDA signed
20
Where pitches come from, and why they are declined. Channels, area by stage, decline reasons and reviewer service.
The portal brings the most pitches: 154 of 359
Northwind Bio, year to date, on the sample data
359pitches
Partnering portal154
BD inbox104
Meeting notes65
Bankers36
Fictional example from this guide
Show the numbers
Part
Value
Partnering portal
154
BD inbox
104
Meeting notes
65
Bankers
36
Bankers bring the fewest pitches and the best fit
Share of each channel's pitches scoring 65 or more, as the sample dashboard shows
Bankers58%
Meeting notes52%
BD inbox41%
Partnering portal34%
Fictional example from this guide
Show the numbers
Item
Value
Bankers
58%
Meeting notes
52%
BD inbox
41%
Partnering portal
34%
Most declines are about strategy: 81 outside the priority list
The reason given in each decline, Northwind Bio, year to date, on the sample data
Outside the area's priority list81
Too early, no human data yet54
Crowded mechanism36
Modality out of scope30
Rights not available17
Fictional example from this guide
Show the numbers
Item
Value
Outside the area's priority list
81
Too early, no human data yet
54
Crowded mechanism
36
Modality out of scope
30
Rights not available
17
Search criteria, fit weights and promises you set yourself
Search criteria. One approved version per area with a named owner, and weights that total 100. Change a weight and every live pitch is scored again.
Promises and the boundary. First reply 10 business days, reviewer view 5, reminders two days ahead, and a confidential hold locked by legal.
16 · Agents and signatures
Six partnering agents draft and suggest; the S&E lead confirms and signs
In shortEach agent has one job and one rule it never breaks. People hold every decision that reaches the outside world: the S&E lead confirms each routing and signs each reply, BD counsel owns the confidential boundary, and each area's owner approves changes to its criteria.
Confidentiality Check
Reads only the cover email and the file labels, before any other agent reads a file. Holds anything marked confidential and tells BD counsel.
Never opens or forwards a held file; it logs name, size, fingerprint and time.
Pitch Reader
Reads decks, portal forms, emails and meeting notes into 11 register fields, each with its slide or page.
Never guesses; an empty field means the pitch did not say.
Duplicate Finder
Finds earlier pitches by target, format, manufacturer, company history and contact, and brings back what was decided and what has changed.
Never merges two records without a person, and always states its reasons.
Fit Scorer
Scores six weighted points against the area's written criteria, quoting evidence for each.
Never uses anything but the approved criteria version.
Router
Suggests the reviewer from routing rules and each person's open load; under fit 50 it suggests a courteous decline.
Never routes alone; a person confirms every routing.
Reply Writer
Drafts the acknowledgment, next-step letter, decline or CDA request in your house style.
Never sends, and never commits to terms; it always restates the non-confidential boundary.
Priya, Maya, Dana and Sam: who decides what on the sample team
Fictional · the people in the sample data
PR
Priya Ranvelle · Director, Search & Evaluation
Confirms every routing and signs every reply.
"Every company that pitches us deserves an answer, even when it's no."
MC
Dr. Maya Chen · Immunology reviewer
Owns the immunology criteria and gets the cited summary, the fit reasons and her own earlier note.
"Tell me if I've seen this molecule before, under any name."
DO
Dana Okafor · BD legal counsel
Owns the confidential boundary and sends the standard mutual CDA.
"If it says confidential, nobody opens it before a CDA."
SP
Sam Patel · BD operations
Runs routing rules, service levels and reports, with reminders two business days ahead.
"I want the late ones before they're late."
Each step lands on an audit trail with who, what and when, kept for seven years in the sample settings. Roles decide who can see and sign what, with maker and checker kept separate: an agent drafts, a person approves, and a criteria change needs the area owner. Botminds is SOC 2 Type II audited and manages information security to ISO 27001.
17 · What goes in and out
Decks, portal forms and banker teasers in; a cited register, fit scores and signed replies out
In shortEvery channel a pitch comes through goes in, along with your earlier decisions and your areas' criteria. A cited register, a map, routed reviews and signed letters come out, and everything connects to the systems your BD team already keeps. Outcome figures here are design targets, measured in the live solution.
Every channel
Non-confidential decks in PDF and PowerPoint
Partnering portal submissions
BD inbox emails and their cover notes
Partnering meeting notes
Bankers' teasers and process letters
From you
Each area's approved search criteria
Earlier pitches and review decisions
Fit weights, promises and routing rules
Your house style for letters
Agents check, read, match, score and draftEvery pitch, as it lands, under your rules
The S&E lead confirms and signs
Every field opens at its page
Outputs
A fit map with a reply clock on each pitch
Opportunity register with cited fields
Fit score and earlier-pitch check
Routing to a named reviewer
Signed replies, on the clock
Funnel and response-time dashboard
Connecting the portal, BD inbox, CRM and document store
System
What moves
Partnering portal
Submissions arrive and receive an acknowledgment with your stated promise
BD inbox and email
The cover note first, then attachments only if nothing marks them confidential; signed replies back out
CRM or deal tracking
Register rows and status, sent from the pitch screen
Earlier decisions
Past pitches and reviewer notes, loaded once, so the first match works on day one
Document store and legal
CDA requests to your counsel's process; held files stay sealed under counsel's control
Design targets for first reply time and reply promise
2.5 days
median first reply, inside a 10-business-day promise. On the sample data, it was 16.5 days in January.
Design target, measured in the live solution
93%
of pitches answered within 10 business days, above a 90% goal.
Design target, measured in the live solution
1.4 hours
of reading and first-pass scoring returned per pitch, of about 1.5 by hand.
Estimate before deployment
The design target cuts the median first reply from 16.5 business days to 2.5
16.5 is the sample company's January figure; 2.5 is a design target, measured in the live solution
Before, sampleDesign target
Median first reply16.5 business days2.5 business days
Fictional example from this guide
Show the numbers
Before, sample
Design target
Median first reply
16.5 business days
2.5 business days
Part C · Are you ready to automate?
Automating inbound partnering triage: what a slow front door costs, what it returns and how to test it
You run search and evaluation, review its pitches, advise on it or answer for its budget. This part is written to you. It says what to measure, what to ask and how to try this on your own past pitches before you commit.
18 · What a slow front door costs
What a slow partnering inbox costs you: small staff hours, then lost reputation and the asset you missed
In shortThe hands-on time is modest, about $100,000 a year on illustrative inputs. The costs that matter are harder to see: senders who stop calling, reviewers who read the same molecule twice, a confidential file someone opened, and a good asset you declined without looking. Only you can measure those.
$101K
a year of loaded time at 450 pitches, 1.5 hours each and $150 an hour.
Our arithmetic; every input is illustrative
30
pitches open at any moment with a 16.5-day median, against about 4.5 at 2.5 days.
Little's law, illustrative volume
$274.3B
of announced biopharma licensing in 2025, the market your front door is competing in.
About 2 in 100 opportunities became a deal in one published funnel
2 in 100
9 deals from about 400 opportunities reviewed, one royalty investor, 2023. Your rate will differ; it shows why a first reader must be quick and why the decisive few must not be lost.
9 deals from about 400 opportunities reviewed, one royalty investor, 2023. Your rate will differ; it shows why a first reader must be quick and why the decisive few must not be lost.
2 of 100
What no one has priced. We found no public figure for the cost of a late reply, the value of an asset declined in error, or hours per pitch. The 1.5 hours used across this guide is an estimate. The vendor claims we read name no dataset. Measure your own.
Auditing last quarter's pitches to find your own numbers
Cost
Where it hides
How to find your number in a week
Time to first reply
Across four channels, in sent mail
Take 50 pitches from last quarter and find the arrival and first-reply dates of each. Report the median and the share on time
Hours per pitch
Fitted around other work
Time ten pitches from arrival to routing, with a stopwatch
Lost pitches
Personal inboxes and conference notes
Ask the five people who attend most conferences to forward last quarter's notes. Count those not in the register
Repeat reads
New codes and renamed companies
Search 100 past pitches by target and company history, and count molecules seen twice
Boundary slips
Forwarded mail; files opened to check
Ask counsel how many marked files were opened last year, and how anyone would know
Wrong declines
In no report at all
Take declines from three years ago and check them against later public deals and Phase 3 trials
Sender goodwill, reviewer attention and a claim you cannot rebut
The second pitch you never getA founder who waited weeks for a form letter takes the next asset elsewhere first.
Your reviewers' patienceA scientist sent weak pitches stops answering, and the good ones wait too.
The claim you cannot rebutYears later, a former sender says you used its secret, and nobody can show who opened what.
The banker's dateA process closes while the teaser waits its turn.
Your own memoryThe person who remembered RGB-07 leaves, and the watch list goes with them.
19 · Your return
What faster partnering triage returns: hours on each pitch, and one good asset kept in play
In shortPut in your own numbers. Hours alone repay a system only at high volume. One asset you would otherwise have missed can repay it many times, and the reply promise has value of its own. The calculator keeps hours and kept assets apart, so you can see which case you are making.
Hours, reply time and repeat reads: where partnering automation pays
Reading time
Fields arrive filled
The reader checks instead of typing, with every value linked to its page.
pitches × (hours by hand − hours checking) × hourly cost
Reply time
The queue shrinks
A drafted answer and a visible clock shorten the wait.
median first reply and share on time, before and after
Memory
Earlier decisions return
A reviewer sees her own note, and the company hears one consistent answer.
repeat pitches caught ÷ repeat pitches in the sample
Reviewer focus
Fewer, better pitches
Those outside the criteria get a true reply without taking a reviewer's time.
share of routed pitches the reviewer keeps
The boundary
A receipt for every held file
The log shows what was held, when, and that nobody read it.
marked files opened before a CDA, target zero
Assets kept
A missed look returned
A pitch that would have sat past a banker's date gets read in time.
assets kept in play × what one is worth to you
Work out your return from pitches a year, hours by hand and the worth of one asset
Every default here is an assumption to replace; no public benchmark exists for any of them. The 1.5 and 0.1 hours follow the estimate used across this guide.
Your volumeTimeAssets and cost
Illustrative yearly value
Hands-on time today, valued$0
Time released, valued$0
Assets kept in play, valued$0
After your yearly cost$0
Expert hours released a year0
Asset value a year needed to cover the cost$0
Formulas, per year: Time today = pitches × hours by hand × hourly cost Time released = pitches × (hours by hand − hours checking) × hourly cost Assets kept = assets × worth of one After your cost = time released + assets kept − yearly cost Asset value needed = yearly cost − time released, never below zero
Not counted: reply time, sender goodwill, reviewer focus or a claim you could rebut. Value a kept asset with care: this one input can outweigh all the others, so the default is only one asset in four years.
At $150,000 a year, hours alone repay the cost at about 700 pitches
Time released per year at 1.4 hours saved a pitch and $150 an hour, by pitch volume; the yearly cost is an assumption
250 pitches a year$52.5K
450 pitches a year$94.5K
714 pitches a year$150K
1,000 pitches a year$210K
2,000 pitches a year$420K
Illustrative · replace with your own numbers
Show the numbers
Item
Value
250 pitches a year
$52.5K
450 pitches a year
$94.5K
714 pitches a year
$150K
1,000 pitches a year
$210K
2,000 pitches a year
$420K
A company with, say, 150 pitches a year and a watchful reader may never recover the hours. That team's case, if it has one, rests on memory and the boundary. Buy on those grounds or wait.
Start here20 · Readiness check
How ready your S&E team is: pitch volume, written criteria, earlier decisions, boundary and sign-off
In shortPick the answer closest to your team today. Eight questions score 0 to 2; the last is for reflection. The meter adds up your score as you go, and each question says why it matters and what a strong answer sounds like. The figures in those answers are examples.
1
Inbound volume
How many pitches does your team receive in a year, across every channel?
Why it mattersVolume decides whether hours can pay for this, or whether the case rests on memory and the boundary.
A strong answer"About 450 last year: 190 through the portal, 130 by email, the rest from bankers and meetings."
2
Reply baseline
Do you know your median first reply and the share answered on time?
Why it mattersNo public benchmark exists, so your own baseline is the only way to show improvement.
A strong answer"Median 14 business days last quarter, and 38% inside our 10-day promise."
3
Written search criteria
Has each therapeutic area written down, and approved, what it wants?
Why it mattersA scorer can only apply what is written. If criteria live in a senior person's head, write them first; that alone helps.
A strong answer"Four areas, each with a dated version and a named owner who approves changes."
4
Earlier decisions
Could you find what your reviewer said about a molecule two years ago, and why?
Why it mattersFinding a repeat needs a history. The richer the record, the better the match on day one.
A strong answer"Three years in a CRM, with the reviewer's reason on most declines."
5
The confidential boundary
Does BD counsel have a written rule for a marked file, and a way to prove it was followed?
Why it mattersA tool can enforce a rule you have. It cannot invent the rule, and counsel must own it.
A strong answer"Hold unopened, log the receipt, reply asking for a CDA. Counsel audits the log each quarter."
6
Who signs a reply
Is one named person accountable for routing and for each letter to a sender?
Why it mattersSoftware drafts. Somebody has to answer for what goes out, and for what it implies about terms.
A strong answer"The S&E director signs; counsel has approved the templates; nothing goes out unsigned."
7
Security and data terms
Have security, privacy and counsel agreed where third parties' decks may be stored and processed?
Why it mattersDecks belong to other people. Portal terms, and your promises to senders, set what you may do with them.
A strong answer"Security has reviewed it: no model training on inputs, a retention period, and deletion on request."
8
Owner and budget
Is there a person and a budget for changing how the front door runs, reviewers included?
Why it mattersReviewers must agree to the clock and the routing. A tool cannot make a scientist answer.
A strong answer"The head of BD owns it, area heads have agreed a 5-day view, and there is money for a pilot."
9
For reflection
If a founder asked what happened to the deck she sent you last spring, could you tell her within a minute?
Why it mattersYour answer lists the gaps: arrival, reader, score, reviewer, reply and reason. Each gap is a candidate job for software.
A strong answerA short, specific list, for example: "Yes for portal pitches. No for anything sent to a person, or noted at a conference."
What your S&E score means
0–6
Explore
Time ten pitches, measure your first reply, and write each area's criteria. Those three steps help with or without a tool.
7–11
Ready to pilot
Replay a past quarter of non-confidential pitches, with repeats and marked files you plant, and compare to what your reviewers decided.
12–16
Ready to implement
Set up for the next live quarter: your criteria, your promises, your signers and your counsel's rule on the boundary.
21 · Questions for any vendor
What to ask a partnering software vendor or scouting firm about confidentiality, citations and scoring
In shortAsk every vendor and adviser the same questions, us included. The answers show how the boundary is enforced, how a field traces to a page, how the score can be challenged, and what happens to other companies' decks.
Ask
A good answer
A warning sign
The confidential boundary
Show me exactly what your system reads before it decides a file is marked confidential.
The cover and the labels, in a logged step, before any other reading. Show the log
"We detect confidential content", which means it read the content
Who can switch that hold off?
Only counsel, and the change is recorded
Any administrator, or a setting nobody can find
Reading and citations
What happens when a deck does not state a field?
The field stays empty and says so
A confident value with no page
Can a reviewer click any value and land on its passage?
Yes, on the slide, highlighted
A citation to the document as a whole
What is your error rate per field, on pitches like ours?
A test on your sample, by field, with the answer key shared
One accuracy figure from a benchmark the vendor wrote
Scoring and matching
Whose criteria score the pitch, and which version?
Yours, dated, with an owner's approval; the version shows on each score
A generic market model
How do you defend against hidden instructions in a deck?
Names the risk, shows its test, and keeps a person on every decision47
Has not heard of it
How do you find a molecule under a new name?
Named clues, stated reasons and a person to merge
A similarity score with no reasons
Data and people
Does any model learn from decks sent to us?
No, in the contract, with a stated retention and deletion route
"Only to improve the service"
Does anything go out without a person?
No. A person signs every letter, and the record shows who
Auto-decline presented as a feature
What credentials do you hold, and what do they cover?
An audit report you can read, with its scope
Certified for something no one can certify
22 · How to start
A six-week replay of last quarter's pitches, before the next live inbound quarter
In shortStart with pitches already answered, so nothing live is at risk. Plant repeats and marked files, keep the answer key, and see what the tool finds. Your reviewers compare it to what they decided. Decide on evidence by week six.
Clear the reuse. Ask counsel whether past non-confidential pitches may be replayed in a restricted workspace.
Pick 100 past pitches from all four channels, including repeats, declines and a few that became deals.
Plant 10 repeats and 5 marked files, renamed and relabeled, and keep the answer key outside the system.
Load your criteria, weights and signers, then run blind.
Compare the scores, fields and matches with what your reviewers did, and decide.
Six weeks ends with a decision before your next inbound quarter
Your teamVendor
Baseline: time ten pitches, measure replies
Clear reuse with counsel; choose 100 pitches
Plant repeats and marked files
Load criteria, weights and signers
Blind replay of all 100
Reviewers compare and correct
Score the results and decide
Week 0246
Illustrative · replace with your own numbers
Show the numbers
Activity
From
To
Baseline: time ten pitches, measure replies
0
2
Clear reuse with counsel; choose 100 pitches
0
2
Plant repeats and marked files
1
2
Load criteria, weights and signers
2
3
Blind replay of all 100
3
4
Reviewers compare and correct
4
5
Score the results and decide
5
6
Replay scorecard: what to count in a partnering triage pilot
Measure
How to count it
A fair bar to set in advance
Marked files read
Of the 5 you planted, how many opened, from the log
Zero
Repeats found
Of the 10 you planted, how many matched with reasons
Your choice; beat a person with a search box
Field accuracy
Correct values ÷ values, by field, on a sample of 25 pitches
Set by field; an empty field beats a wrong one
Routing agreement
Pitches sent where your team sent them, and why it differed
Review every disagreement, since some will be your errors
Letters signed unchanged
Drafts counsel and the S&E lead would send as written
Every reply free of terms; style is secondary
Minutes per pitch
Stopwatch, from open to signed, against your baseline
Your baseline, compared honestly
The full working-session questions: 12 questions in four groups
Bring S&E, a reviewer from each area, BD counsel, BD operations and security.
A
Your last quarter of pitches, measured
A1
How many arrived, by channel, and how many reached the register?
A2
What were the median and the worst first reply?
A3
How many had a date in them, and did we meet it?
B
Search criteria, weights and cut-offs
B1
Who owns each area's criteria, and when did they last change?
B2
If we scored last year's pitches, what would we route that we declined?
B3
Which point would an area head change first, and why?
C
The confidential boundary and China-origin assets
C1
What does counsel want done with a marked file, and who may release one?
C2
Which facts does counsel need recorded on a China-origin pitch, given the proposed outbound rule?
C3
Who keeps triage readers on the restricted trading list?
D
Letters, reviewers and promises
D1
Which words must never appear in a first reply?
D2
What will reviewers commit to, and who follows up when they miss it?
D3
What promise do we print on the portal, and can we keep it?
23 · Questions buyers ask
Answers on search and evaluation, non-confidential decks, CDAs and China licensing
In shortThe questions people search for, each answered on its own.
What is partnering opportunity triage?
It is the first sorting of pitches a drug company receives from outside companies, through a partnering portal, the business development (BD) inbox, bankers and conference meetings. A reader checks each one is safe to open, reads it, looks for earlier pitches, scores fit against the therapeutic area's criteria, and routes it to a reviewer or declines it. It decides who spends time on what, and leaves the deal decision to others.
What does search and evaluation do in pharma?
Search and evaluation, or S&E, is the business development function that finds outside drug assets and judges them. Search means looking for assets that fit the company's strategy; evaluation means assembling scientific, commercial and legal views on the promising ones. Triage of inbound pitches is the part of that work that arrives uninvited.
What should a non-confidential pitch deck include?
Partner pages say little, but readers look for the mechanism and targets, the first disease, the stage reached, headline clinical data with patient numbers and a control, patent status and expiry, the rights on offer and a named contact. It should state plainly that it is non-confidential. Anything you would not want a competitor to read belongs behind a confidential disclosure agreement (CDA).
What happens if a company sends a confidential file without a CDA?
A careful recipient holds the file unopened, logs that it arrived, tells counsel and replies that it cannot receive confidential material before an agreement is in place. It then offers a confidential disclosure agreement (CDA), asks for a non-confidential summary, and offers to return or delete the file. Opening it could expose the recipient's own research to a later claim, which is why portals ask for non-confidential material only.5
How long should a pharma company take to reply to a licensing pitch?
No public standard exists, and we found no independent survey of first-reply times. A team can set its own promise; this guide's fictional example uses 10 business days for a first reply and 5 for a reviewer's view. Whichever you choose, publish it, count business days the same way each time, and report both the median and the share on time.
How do you score a partnering opportunity?
A common method gives weights totaling 100 to a few points, such as strategic fit, differentiation at launch, human evidence, modality, rights and competition. A reader scores how well the pitch meets each, and the weighted sum sorts the queue. It is only useful if each point carries a reason, the criteria carry an approved version, and the cut-offs have been tested against past decisions. It does not value the asset.
How do you tell if an asset has been pitched before under a different name?
Search on what is hard to change: targets and antibody format, manufacturer and cell line, patent family, contact people and the company's own history. A code and a company name are the first things to change. A good match states its reasons, brings back the earlier decision and what has changed, and waits for a person to merge the records.
Do the 2026 outbound investment rules stop licensing drugs from China?
Not as proposed. Treasury's proposal of October 26, 2026 adds biotechnology to the outbound investment program, and law firms read it as not governing pure licensing-only transactions, though deals with equity or a joint venture may be caught.15,24 Comments close December 7, 2026, and a bill, BINSA, would add licensing from a covered foreign person to the transactions the program covers.13,14 Take counsel's advice on any deal.
Does the BIOSECURE Act affect in-licensing?
It is a procurement rule. Federal agencies may not buy biotechnology equipment or services from listed companies or contract with firms that use them to perform the contract, and federal loan and grant money may not pay for them; the section does not mention licensing.11,22 The first list from the Office of Management and Budget is due by December 18, 2026.11,23 It matters at triage because a deck names a manufacturer, and a future partner's contracts may be touched by who that is.
Is AI used for pitch triage regulated by FDA?
FDA's January 2025 draft guidance on AI says it does not address AI used for operational efficiencies that do not affect patient safety, drug quality or the reliability of study results, and we read triage as such a use.32 A pitch register is not a record under 21 CFR Part 11, FDA's electronic records rule, either, unless it later feeds a regulated file.33 The practical risks are confidentiality, wrong citations and hidden instructions in files, and they need your own controls.
Does Botminds send replies or decide deals on its own?
No. In Partnering Opportunity Triage, the Reply Writer drafts in your house style, makes no commitment on terms and never sends. The Router suggests a reviewer. A person confirms each routing and signs each reply, and the audit trail records who did what and when.
What is a CDA in pharma business development?
A confidential disclosure agreement is the pharma industry's name for a non-disclosure agreement. It is signed before confidential data moves, and it sets what is covered, for how long and for what purpose. Read any residuals clause first, since it may let a recipient use what its people remember.36
24 · One-page summary
Partnering opportunity triage on one page: the method, the November 2026 rules, readiness and terms
Print this page
In shortThe whole guide on one screen: the method, the rules as of November 2026, the readiness scale and the terms.
The method
Bring every channel into one register: portal, inbox, bankers and meeting notes.
Check the cover and labels first. Hold anything marked confidential, unopened, and log the receipt.
Read each pitch into the same fields, each with its page. Empty means the pitch did not say.
Search on targets, format, manufacturer, people and company history. Bring back the earlier decision.
Score against the approved version of the area's criteria, with a reason per point.
Route to a named reviewer, or decline with the true reason and a way back.
Reply inside your promise, sign each letter, and leave terms out.
Measure the median, the share on time, and look back at old declines each year.
As of November 2026: Treasury's biotechnology outbound rule is proposed, with comments to December 7; law firms read pure licensing as outside it. BINSA is a bill. BIOSECURE is law, with OMB's first list due December 18. The expanded HSR form is vacated, with an appeal pending. Panuwat awaits a Ninth Circuit opinion. FDA's AI guidance is a draft, and does not address operational uses that leave study results untouched.
14 terms
Search and evaluation (S&E)
The BD function that finds outside drug assets and judges them.
Partnering opportunity
An asset an outside company offers to license or co-develop, usually through a portal, the company's web form.
Asset
A drug or drug candidate that a company owns and could license.
Non-confidential deck
An overview a sender is content to show without a contract.
CDA
Confidential disclosure agreement, signed before confidential data moves.
Residuals clause
CDA wording that lets a recipient use what its people remember.
Teaser
A banker's short anonymous summary, often with a bid date.
Process letter
A banker's letter setting out the steps and dates of a sale process.
Search criteria
What an area has said it wants, in an approved version.
Fit score
A weighted sum that sorts the queue against those criteria.
Upfront
Money paid at signing, a small part of an announced deal.
Milestones
Later payments that depend on trial, approval or sales results.
rNPV
Risk-adjusted net present value: a drug's future cash, discounted and weighted by its odds.
COINS Act
The 2025 law behind Treasury's outbound investment rules.
25 · Sources
Sources
Accessed November 2026. Legal and regulatory status statements are as of November 2026.
Mintz, "Doing Life Sciences Deals in 2024", panel report, April 22, 2024. mintz.com
Lubkeman, Kronimus, Hansen, "Building Effective Business Development in Pharma", BCG, January 19, 2021. bcg.com
Truex, "Just a Little Patience: In-licensing from Biopharma", LifeSciVC, March 20, 2018. lifescivc.com
Royalty Pharma at the Morgan Stanley Global Healthcare Conference, edited transcript, September 5, 2024 (figures for 2023). royaltypharma.com
PepsiCo innovation portal on yet2, frequently asked questions, read November 2026. pepsico.yet2.com
Eisberg, "Pharma R&D: What's in the pipeline?", Chemistry & Industry, issue 5, 2026, on Citeline's Pharma R&D Annual Review 2026. soci.org
Informa Connect, BIO-Europe Spring, previous events: one-to-one meetings and delegates, 2007 to 2026. informaconnect.com
BIO International Convention, event summary for 2025 (partnering meetings and registrants, read only in an excerpt, because the page would not open). convention.bio.org
KFF Health News Morning Briefing, February 11, 2022, on the Oncologic Drugs Advisory Committee vote of February 10, 2022. kffhealthnews.org
Paul, Weiss, "Federal Jury Finds Defendant Liable in SEC 'Shadow Trading' Case", April 2024. paulweiss.com
Public Law 119-60, National Defense Authorization Act for Fiscal Year 2026, section 851, approved December 18, 2025. govinfo.gov
Katten, "FTC Reverts to Prior HSR Form After Fifth Circuit Denies Stay Pending Appeal", March 23, 2026, on Chamber of Commerce v. FTC, No. 26-40094 (5th Cir.). katten.com
H.R. 9102, Biotech Investment National Security Act of 2026, as introduced June 2, 2026, referred to the Committee on Financial Services. govinfo.gov
S. 5316, Biotech Investment National Security Act of 2026, as introduced August 6, 2026, referred to the Committee on Banking, Housing, and Urban Affairs. govinfo.gov
US Treasury, "Outbound Investment Security Program Regulations", proposed rule, 91 FR 67396, October 26, 2026, comments due December 7, 2026. govinfo.gov
18 U.S.C. 1839, definitions of trade secret and improper means (Defend Trade Secrets Act). law.cornell.edu
17 CFR 243.100 (Regulation FD), general rule and exclusions. law.cornell.edu
Akin Gump, "Both Sides Receive Skepticism from Ninth Circuit in SEC v. Panuwat Oral Argument", June 17, 2026 (we read an excerpt, not the full page, which would not open). akingump.com
SIGA Technologies, Inc. v. PharmAthene, Inc., No. 20, 2015 (Del. December 23, 2015, corrected December 28, 2015). shulmanrogers.com
SIGA Technologies, Form 10-K for fiscal 2016, on the judgment, its interest and its payment. sec.gov
16 CFR 801.2(g), transfers of patent rights within NAICS Industry Group 3254, 2025 edition. govinfo.gov
Goodwin, "Final FY 2026 NDAA Includes BIOSECURE Provisions", December 2025. goodwinlaw.com
Arnold & Porter, "National Security Controls and the Life Sciences Sector", June 16, 2026, citing Reuters of February 13, 2026 on cross-border licensing value. arnoldporter.com
Goodwin, "Heads Up: COINS Act Proposal Takes Aim at Biotech and AI Investment in China", October 28, 2026. goodwinlaw.com
Holland & Knight, "Outbound and Down: Biotech Joins Semiconductors, Quantum and AI", October 26, 2026. hklaw.com
National Law Review, "Bipartisan Senate Bill Would Prevent Offshoring of Biotech Industry", August 26, 2026, on S. 5316 and H.R. 9102. natlawreview.com
CASRAI, report on the House letter to FDA on clinical trial data generated in China, August 2026 (a secondary report; the letter itself was not found). casrai.org
Foley Hoag, "Implementing COINS: Treasury Proposes Restricting Outbound Investment on Biotechnology", October 30, 2026. foleyhoag.com
House Select Committee on China, "Moolenaar: New Biotech Investment Rules Help Stop CCP Takeover of Medicine Supply Chains", October 23, 2026. chinaselectcommittee.house.gov
Pharmaceutical Executive, "White House officials drafting executive order on treatments discovered in China", report, September 11, 2025. pharmexec.com
FDA, "Considerations for the Use of Artificial Intelligence to Support Regulatory Decision-Making for Drug and Biological Products", draft guidance, January 2025, Docket FDA-2024-D-4689. fda.gov
Abbott, "Partners in innovation: licensing", read November 2026. abbott.com
AstraZeneca, "Partnering", read November 2026. astrazeneca.com
Farrer & Co, "Remember, remember: residuals clauses in NDAs, risks and how to manage them" (we read an excerpt, not the full PDF, which would not open). farrer.co.uk
FDA, "Step 3: Clinical Research", The Drug Development Process, read November 2026. fda.gov
BIO, Informa Pharma Intelligence and QLS Advisors, "Clinical Development Success Rates and Contributing Factors 2011-2020", February 2021. go.bio.org
J.P. Morgan with DealForma data, "Q3 2026 Biopharma Licensing and Venture Report", October 2026, data through September 30, 2026. jpmorgan.com
Bilzin Sumberg, "Caveat Emptor: Noncompliance with a Nonbinding Term", March 2016. bilzin.com
GlobalData, "Big pharma prepare for next patent cliff", July 4, 2025. globaldata.com
Pharmaceutical Executive, Jacobus, "Deepening Ties: Why China is Becoming Big Pharma's Most Essential R&D Partner", June 9, 2026. pharmexec.com
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OWASP, "LLM01:2025 Prompt Injection", OWASP Top 10 for LLM Applications 2025. genai.owasp.org
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