NAMs Evidence Package demo
Safety endpoints against new approach methods on one grid, with the animals each covered endpoint could spare. 1:13
What the demo shows
A new approach methods solution for toxicologists that makes the case to replace animal tests.
Seven agents read every study, assay and model report, grade each safety endpoint against each new approach method, and count the animals each covered endpoint could spare. When a new assay run arrives the cell is regraded and the count moves; the package writer drafts the justification and FDA questions and the critic checks every claim against its source. The toxicologist and the regulatory lead sign.
Transcript
- NAMs Evidence Package builds the case to replace animal tests for toxicologists.
- One antibody program can use 144 monkeys.
- Veltrimab's endpoints run down the side, new approach methods across.
- Each cell is graded from cited evidence and counts the animals it spares.
- Hepatotoxicity holds 48 monkeys.
- The liver chip used one donor, not three.
- A three-donor liver chip run arrives, and Lena adds it.
- Agents regrade it. Hepatotoxicity turns green, and the counter rises by 48.
- All eight FDA expectations met.
- The package is ready for two signatures.
- The case for fewer animal studies, ready to sign in days.
- Built on Botminds: agents, data, screens, and governance on one platform.
Transcribed from the film’s narration. Captions are on the player.